Activates metabolic pathways
Triggers AMPK signaling to enhance glucose uptake and fatty acid oxidation.
MOTS-C
The mitochondrial peptide for metabolic health and cellular energy.
Starting at
$179/month
Includes doctor review & treatment plan
All plans include doctor review, personalized treatment plan, and 24/7 provider access.
Unlimited 24/7 support
No hidden fees
No insurance required
Same price, every dose
- Origin
- Mitochondrial-derived
- Target
- AMPK pathway
- Form
- Injectable peptide
- Availability
- Prescription only
MOTS-C is a peptide naturally produced by your mitochondria that helps regulate metabolism. It activates AMPK, a key enzyme involved in energy balance, glucose uptake, and fat burning.
No. While MOTS-C activates some of the same metabolic pathways as exercise, it is not a replacement for physical activity. It is best used as a complement to a healthy lifestyle and exercise routine.
MOTS-C may benefit individuals looking to support metabolic health, improve insulin sensitivity, or enhance cellular energy production — particularly those who have noticed age-related metabolic changes.
Peptide Library
Each plan may include several of the following formulations.
RECOVERY
CJC/Ipamorelin
Stimulates natural growth hormone release to aid recovery and body composition.
Learn more →
METABOLIC
MOTS-C
Supports fat metabolism without affecting blood sugar.
Learn more →
METABOLIC
Tesamorelin
Reduces visceral fat and supports metabolic health.
Learn more →
RECOVERY
BPC-157
Promotes healing and recovery of tissues and joints.
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ENERGY
Epitalon
Supports cellular energy production and longevity.
Learn more →
COGNITIVE
Semax
Enhances cognitive function and mental clarity.
Learn more →
COGNITIVE
Selank
Improves focus and reduces anxiety.
Learn more →
METABOLIC
AOD-9604
Stimulates fat breakdown and supports weight management.
Learn more →
RECOVERY
Thymosin Beta-4
Accelerates wound healing and tissue repair.
Learn more →
SEXUAL HEALTH
PT-141
Enhances sexual desire and arousal through central nervous system activation.
Learn more →
RECOVERY
GHK-Cu
Promotes skin health and collagen production.
Learn more →
COGNITIVE
Cerebrolysin
Supports brain health and cognitive performance.
Learn more →
How MOTS-C works
MOTS-C is encoded in the mitochondrial genome and acts as a signaling molecule that activates the AMPK (AMP-activated protein kinase) pathway — the body's master metabolic regulator. By activating AMPK, MOTS-C enhances glucose uptake in skeletal muscle, improves insulin sensitivity, promotes fatty acid oxidation, and supports mitochondrial biogenesis. It essentially mimics some of the metabolic benefits of exercise at the cellular level.
Clinical evidence
Research published in Cell Metabolism demonstrated that MOTS-C activates AMPK and improves glucose metabolism in both in vitro and in vivo models. Studies in aging mouse models showed that MOTS-C administration improved insulin sensitivity, reduced fat accumulation, and enhanced physical performance. Human observational studies have found that circulating MOTS-C levels decline with age and are inversely correlated with metabolic dysfunction.
Benefits
Supports insulin sensitivity
Improves the body's ability to regulate blood sugar naturally.
Promotes mitochondrial health
Supports the growth of new mitochondria and enhances cellular energy production.
Exercise-mimetic effects
Activates metabolic pathways similar to those triggered by physical exercise.
Key takeaways
- Mitochondrial-derived peptide that activates AMPK metabolic pathways
- Mimics some cellular benefits of exercise
- Supports insulin sensitivity and fat metabolism
- Levels naturally decline with age
- Promising research in metabolic health and longevity
Dosing & administration
MOTS-C is typically administered as a subcutaneous injection several times per week. Protocols vary based on individual metabolic goals and health status. Your provider will determine the optimal dosing schedule after reviewing your health profile and lab work.
All dosing is determined by your licensed provider based on your individual health profile. Do not self-administer without medical supervision.
The science behind it
Proven science
Every peptide we offer is backed by peer-reviewed research and clinical data. Our medical team stays current with the latest findings to ensure your protocol reflects the best available science.
Discreet delivery
Your medications arrive in unmarked, temperature-controlled packaging shipped directly from licensed compounding pharmacies. Privacy and quality guaranteed at every step.
Doctor-supervised safety
Every treatment is prescribed and monitored by a licensed physician. Regular check-ins, lab reviews, and dosage adjustments ensure your peptide therapy is safe and effective throughout your journey.
Bundle savings
Savings apply when multiple peptides are prescribed.
| BUNDLE SIZE | INCLUDED | SAVINGS |
|---|---|---|
| 2 Peptides | Simple paired therapy | SAVE 20• |
| 3 Peptides | Multi-pathway plan | SAVE 30• |
| 4 Peptides | Full personalized set | BEST VALUE |
•• Results vary. Prescribed only when clinically appropriate.
Medication made affordable
Capsules
$179/mo
Includes doctor review & treatment plan
Single Peptide
$229/mo
Includes doctor review & treatment plan
Double Combo
$349/mo
Includes doctor review & treatment plan
Triple Combo
$479/mo
Includes doctor review & treatment plan
All plans include a doctor review, personalized treatment plan (if approved), and 24/7 access to a licensed provider in your state.
Frequently asked questions
MOTS-C is a peptide naturally produced by your mitochondria that helps regulate metabolism. It activates AMPK, a key enzyme involved in energy balance, glucose uptake, and fat burning.
No. While MOTS-C activates some of the same metabolic pathways as exercise, it is not a replacement for physical activity. It is best used as a complement to a healthy lifestyle and exercise routine.
MOTS-C may benefit individuals looking to support metabolic health, improve insulin sensitivity, or enhance cellular energy production — particularly those who have noticed age-related metabolic changes.
Many patients notice improvements in energy and metabolic markers within 4-6 weeks. Significant changes in body composition and metabolic health typically develop over 8-12 weeks.
Yes, MOTS-C pairs well with other metabolic peptides like GLP-1 therapy or AOD-9604 under physician guidance. Your provider will design a protocol based on your individual needs.
Clinician-Led Care
Eligibility check
Quick online assessment
Consultation
Licensed provider reviews your medical history
Prescription
Medication shipped directly once approved
Follow-ups
Ongoing support and check-ins
Secure telehealth · GDPR-compliant · Pharmacy-grade compounding.
Check eligibility →
Not for self-administration. Reviewed by a medical provider.
Related treatments
METABOLIC
GLP-1 Therapy
Clinically studied peptides designed to target metabolism, recovery, energy, and longevity.
Learn more →METABOLIC
AOD-9604
The fat-burning fragment of growth hormone for targeted weight management.
Learn more →ENERGY
Epitalon
The telomere peptide for cellular longevity and anti-aging.
Learn more →Begin your peptide therapy journey
Doctor-guided peptide treatments personalized to your health goals. Start with a free consultation.
Starting at
$179/month
Includes doctor review & 24/7 provider access
All plans include doctor review, treatment plan, and 24/7 provider access.